Key result
Weight and abdominal girth were key determinants of tidal volume requirement during mechanical ventilation for general anaesthesia, yielding a predictive regression equation with an adjusted R2 of 0.813.
Why the study?
Although tidal volume relates to age, height, weight, chest circumference, and abdominal girth, it was unclear which factors have the strongest association and can accurately predict tidal volume requirement during mechanical ventilation.
Cross-Sectional (n=100)
No
Tidal volume requirement during mechanical ventilation for general anaesthesia can be accurately predicted using a regression equation based on patient weight and abdominal girth.
Answers are grounded in this paper and cite their sources.
May aid individualized tidal volume selection in anaesthesia; leaves open prospective validation before practice change.
Background: Evidence that tidal volume (TV) is related to age, height, weight, chest circumference, and abdominal girth exists. However, it is unclear which of these has the strongest association with TV. This study aimed to investigate the main factors associated with TV and determine a method for accurately predicting TV requirement during mechanical ventilation. Methods: From December 2019 to January 2021, we enrolled 133 patients who were scheduled for surgery. Their age, height, weight, abdominal girth, and chest circumference were recorded. Intraoperatively, at 30 minutes after mechanical ventilation during general anaesthesia, the TV was increased or decreased by 25 ml if the partial pressure of carbon dioxide (PaCO2) was > 45 mmHg or < 35 mmHg, respectively. This was continued until we observed two consecutive PaCO2 values between 35 and 45 mmHg. The TV setting was recorded at this point. Linear regression and multiple regression analyses were performed. Results: The data of 100 patients were analysed. Linear regression analysis showed significant univariate correlations between age, weight, height, abdominal girth, chest circumference, and TV requirement. (all P ≤ 0.049). Multiple linear regression analysis showed that weight and abdominal girth were key determinants of TV requirement (both P < 0.001). The adjusted R2 for the regression equation was 0.813. The regression equation for accurately predicting TV requirement was Y = 312 + 5.717X1 - 2.798X2 (Y, TV requirement; X1, weight; and X2, abdominal girth). Conclusion: TV requirement during mechanical ventilation for general anaesthesia can accurately be set based on weight and abdominal girth.
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Shen et al. (2021) conducted a cross-sectional in General anaesthesia for surgery (n=100). Weight and abdominal girth was evaluated on Tidal volume requirement to maintain PaCO2 between 35 and 45 mmHg (Adjusted R2 0.813, p=<0.001). Weight and abdominal girth were key determinants of tidal volume requirement during mechanical ventilation for general anaesthesia, yielding a predictive regression equation with an adjusted R2 of 0.813.
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