Key result
The combination of 0.5 MAC isoflurane and 0.05 mg/kg morphine significantly reduced myocardial infarct size compared to control (18% vs 41%; P<0.05).
Why the study?
Does the combination of morphine and isoflurane reduce myocardial infarct size and apoptosis in a rabbit model of ischemia-reperfusion injury?
Population
Rabbits instrumented for hemodynamic measurement and subjected to a 30-min coronary occlusion followed by 3…
Comparison
Isoflurane, morphine, or their combination… vs 0.9% saline (control)
Design
Preclinical
Follow-up
3 hours of reperfusion
Authors
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Hypothesis-generating for combined postconditioning in ischemia-reperfusion; does not support clinical use in myocardial infarction.
Does the combination of morphine and isoflurane reduce myocardial infarct size and apoptosis in a rabbit model of ischemia-reperfusion injury?
Absolute Event Rate: 18% vs 41%
p-value: p=< 0.05
Morphine enhances isoflurane-induced postconditioning against myocardial infarction by activating PI3K and opioid receptors, reducing apoptotic cell death in a rabbit model.
Weihrauch et al. (2005) studied Myocardial infarction and reperfusion injury (n=108). Isoflurane and morphine combination vs. 0.9% saline (control) was evaluated on Infarct size (% of left ventricular area at risk) (p=< 0.05). The combination of 0.5 MAC isoflurane and 0.05 mg/kg morphine significantly reduced myocardial infarct size compared to control (18% vs 41%; P<0.05).
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