Key result
Higher blood concentrations of lipocalin-2 and IL-6 were associated with increased odds of significant coronary stenoses in overweight men.
Why the study?
The concentrations of adipokines and their associations with proinflammatory cytokines in overweight men with coronary atherosclerosis needed to be studied.
Case-Control (n=119)
Elevated blood concentrations of lipocalin-2 and IL-6 are associated with an increased probability of clinically significant coronary stenosis in overweight men with coronary atherosclerosis.
Answers are grounded in this paper and cite their sources.
Higher lipocalin-2 and IL-6 may mark stenosis risk in overweight men; hypothesis-generating, needs prospective validation before any clinical use.
Aim To study concentrations of adipokines and their associations with proinflammatory cytokines in overweight men with coronary atherosclerosis. Material and methods This study included 79 men aged 45-60 years with atherosclerosis who had undergone coronary endarterectomy during a coronary bypass surgery, and were overweight (body weight index (BWI), 25.0-29.9 kg /m2). Based on a histological analysis of plaques, the patients were divided into two subgroups: 43 men with stable atherosclerotic plaques and 36 men with unstable plaques in coronary arteries. The control group consisted of 40 age- and BWI-matched men without clinical manifestations of IHD. Blood concentrations of adipokines, including adiponectin, adipsin, lipocalin-2, resistin, and plasminogen 1 activator inhibitor were measured by a multiplex analysis with a MILLIPLEX MAP Human Adipokine Panel 1. Concentrations of proinflammatory cytokines, including tumor necrosis factor α (TNF- α), interleukin (IL)-1β, IL-6, and C-reactive protein (CRP) were measured by enzyme immunoassay. Results The blood concentration of lipocalin -2 was higher in patients with coronary atherosclerosis and stable or unstable atherosclerotic plaques than in the control group (p<0.01). Both subgroups of men with coronary atherosclerosis were characterized by significant differences from the control group in concentrations of TNF-α (p<0.05), CRP, and IL-6 (p<0.01). The most significant direct correlations were found between adipokines and TNF-α, IL-6, and CRP (p<0.01). Results of a logistic regression analysis showed that relative odds for the presence of significant coronary stenoses increased with increasing blood concentrations of lipocalin-2 (OR=1.005, 95 % CI: 1.002-1.008, р=0.011) and IL-6 (OR=1.582 , 95 % CI: 1.241-2.017, р=0.001).Conclusion The changes in blood concentrations of adipokines associated with higher levels of proinflammatory cytokines may represent a factor that increases the probability of clinically significant coronary stenosis in overweight men with coronary atherosclerosis.
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Шрамко et al. (2022) conducted a case-control in Coronary atherosclerosis and overweight (n=119). Blood concentrations of lipocalin-2 vs. Lower concentrations was evaluated on Presence of significant coronary stenoses (OR 1.005, 95% CI 1.002-1.008, p=0.011). Higher blood concentrations of lipocalin-2 and IL-6 were associated with increased odds of significant coronary stenoses in overweight men.
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