Key result
The adiponectin gene SNP+276T allele was associated with a decreased risk of CHD in the Chinese Han population (OR 0.67; 95% CI 0.54-0.83), whereas SNP+45 showed no significant association.
Why the study?
Are adiponectin gene polymorphisms (+45T→G and +276G→T) associated with the risk of coronary heart disease in the Chinese Han population?
Meta-Analysis (n=4,303)
Are adiponectin gene polymorphisms (+45T→G and +276G→T) associated with the risk of coronary heart disease in the Chinese Han population?
Odds Ratio: 0.67 (95% CI 0.54–0.83)
The adiponectin gene polymorphism SNP+276T allele is associated with a decreased risk of coronary heart disease in the Chinese Han population, whereas SNP+45 is not.
May inform CHD risk models in Chinese Han; leaves open prospective validation and causal inference.
OBJECTIVE: Variants of adiponectin gene have been reported to be associated with coronary heart disease (CHD), but the available data on this relationship are inconsistent. A meta-analysis was performed to quantitatively analyse the association of adiponectin gene polymorphisms with coronary artery disease using previous case-control studies in Chinese Han populations. METHODS: Several electronic databases were searched for relevant articles up to January 2011. After data collection and gene loci selection, a meta-analysis was performed to assess heterogeneity, combine results and evaluate variations. Publication bias was examined by the Egger's linear regression test. Hardy-Weinberg equilibrium (HWE) test and by omitting one study at a time was employed for the sensitivity analysis. RESULTS: Eleven studies covering 4303 subjects focusing on two polymorphisms [+45T→G (rs2241766) and +276G→T (rs1501299)] in the adiponectin gene and risk of CHD were included in the meta-analysis. Combined analyses of studies of the SNP+45 showed no significant overall association with CHD, yielding ORs of 1·03 (0·80, 1·34) and 1·32 (0·86, 2·03) under a dominant and recessive model, respectively, with strong evidence of heterogeneity. Similar results were also obtained in other genetic models. Concerning SNP+276, a significantly decreased CHD risk was observed under a dominant model, a codominant model and a allele contrast model, with an odds ratio of 0·67 (0·54, 0·83), 0·77 (0·62, 0·94) and 0·69 (0·55, 0·86), respectively. Sensitivity analysis confirmed the reliability and stability of this meta-analysis. CONCLUSIONS: The accumulated evidence suggested that the adiponectin gene polymorphism, SNP+45, is not associated with CHD, but the SNP+276T allele might be associated with decreased risk of CHD in the Chinese Han population. More well-designed large studies are required for the validation of this association.
No takes yet. Share an insight, caveat, or question.
Zhang et al. (2011) conducted a meta-analysis in Coronary heart disease (n=4,303). Adiponectin gene polymorphism SNP+276T allele vs. Reference allele was evaluated on Coronary heart disease (OR 0.67, 95% CI 0.54-0.83). The adiponectin gene SNP+276T allele was associated with a decreased risk of CHD in the Chinese Han population (OR 0.67; 95% CI 0.54-0.83), whereas SNP+45 showed no significant association.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: