Key result
ADIPOQ +45T>G allele linked to ~24% lower CAD risk, magnified by optimal vascular profile.
Why the study?
The protective effect of the +45T >G polymorphism in ADIPOQ on CAD risk and its interaction with metabolic risk factors in a Chinese population was unclear.
Case-Control (n=1,318)
No
Odds Ratio: 0.76 (95% CI 0.64–0.89)
p-value: p=0.001
Should not guide CAD risk stratification or testing; hypothesis-generating for ADIPOQ-metabolic interactions in larger cohorts.
BACKGROUND: The protective effect of +45T >G polymorphism in the adiponectin gene (ADIPOQ) on coronary artery disease (CAD) has been demonstrated in European populations, so this study investigated the effect of +45T >G polymorphism on the risk of CAD and its interactions with other metabolic risk factors in a Chinese population. METHODS AND RESULTS: The +45T >G polymorphism (rs2241766) of ADIPOQ was genotyped in 600 patients with angiographically diagnosed CAD and in 718 controls. The G allele at the +45T >G polymorphism was associated with a lower risk of CAD (odds ratio (OR), 0.76; 95% confidence interval (CI), 0.64-0.89; P=0.001). The protective effect of the G allele at +45T >G polymorphism was magnified at blood pressure <140/90 mmHg (OR, 0.65; 95%CI, 0.51-0.82; P=0.0004), but disappeared at blood pressure >or=140/90 mmHg (OR, 0.98; 95%CI, 0.76-1.28; P=0.93), indicating an interaction between +45T >G polymorphism and blood pressure on CAD risk (P=0.02 for interaction). A similar interaction was also observed between plasma cholesterol level and the +45T >G polymorphism. CONCLUSIONS: An association of ADIPOQ genetic polymorphism with CAD risk is modified by traditional risk factors, such as blood pressure and plasma cholesterol level.
No takes yet. Share an insight, caveat, or question.
Chang et al. (2009) conducted a case-control in Coronary Artery Disease (n=1,318). G allele at the +45T>G polymorphism of ADIPOQ vs. T allele was evaluated on Risk of coronary artery disease (OR 0.76, 95% CI 0.64-0.89, p=0.001). The G allele at the ADIPOQ +45T>G polymorphism was associated with a lower risk of coronary artery disease (OR 0.76), an effect magnified by lower blood pressure and cholesterol levels.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: