Key result
Theiler's murine encephalomyelitis virus (TMEV) infection induced transient afebrile seizures in approximately 50% of C57BL/6 mice.
TMEV infection in C57BL/6 mice provides a novel model for investigating viral and immune contributions to seizure disorders.
Provides a novel model for viral-immune seizure mechanisms; leaves open translation to human epilepsy.
PURPOSE: We demonstrate the establishment and characterization of a novel virus infection-induced seizure model in C57BL/6 mice. METHODS: C57BL/6 mice were infected with Theiler's murine encephalomyelitis virus (TMEV) or mock infected. Mice were followed for seizures, weight change, body temperature, motor function (righting reflex, rotorod) and neurological manifestations (inflammation [perivascular cuffing], pyknotic neurons, transforming growth factor [TGF]-beta expression). RESULTS: C57BL/6 mice are susceptible to seizures induced by TMEV infection. Approximately 50% of C57BL/6 mice develop transient afebrile seizures. Motor function and coordination are impaired in seized mice. Pyramidal neuron pyknosis and TGF-beta expression correlate with seizure activity in the hippocampus. DISCUSSION: The characterization of this model will enable the investigation of viral and immune contributions in the central nervous system to the development of seizure disorders in humans.
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Libbey et al. (2008) studied Seizures. Theiler's murine encephalomyelitis virus (TMEV) infection vs. Mock infection was evaluated on Development of transient afebrile seizures. Theiler's murine encephalomyelitis virus (TMEV) infection induced transient afebrile seizures in approximately 50% of C57BL/6 mice.
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