Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 1, 1993Epidemiology and InfectionOpen Access

Characterization of monoclonal antibodies against a type SAT 2 foot-and-mouth disease virus

View Full Paper
Ask AI
Bookmark
Share

Population

South African Territories 2 foot-and-mouth disease virus and 73 SAT 2 field isolates

Design

Preclinical

Authors

JCJ. R. CrowtherUNSW SydneyCRC RoweRBR.N. ButcherWillis-Knighton Cancer Center

Discussion

Loading...

Member takes

Implication

Supports epitope-focused SAT2 FMDV vaccines; hypothesis-generating pending in vivo protection data.

Structured PICO

P
Population
South African Territories 2 (SAT 2) foot-and-mouth disease virus (isolate Rho 1/48) and 73 SAT 2 field isolates
I
Intervention
12 monoclonal antibodies (MAbs) against SAT 2 FMD virus
O
Outcome
Characterization of MAbs including binding, neutralization, and identification of escape mutantssurrogate

This study provides the first characterization of monoclonal antibodies against SAT 2 foot-and-mouth disease virus, identifying key antigenic sites on the VP1 loop region.

Cite This Study

Crowther et al. (1993) studied this question.

synapsesocial.com/papers/6a8af5d3a42d46e0ffcaa47fhttps://doi.org/10.1017/s0950268800057083
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neutralization of Foot-and-Mouth Disease Virus Can Be Mediated Through Any of at least Three Separate Antigenic Sites1987 · 175 citations
  2. 2Neutralizing Epitopes of Type O Foot-and-Mouth Disease Virus. I. Identification and Characterization of Three Functionally Independent, Conformational Sites1989 · 86 citations
  3. 3Evidence for At Least Four Antigenic Sites on Type O Foot-and-Mouth Disease Virus Involved in Neutralization; Identification by Single and Multiple Site Monoclonal Antibody-resistant Mutants1989 · 99 citations
  4. 4Antigenic sites on foot-and-mouth disease virus type A101988 · 179 citations
  5. 5Demonstration of Neutralizing and Non-neutralizing Epitopes on the Trypsin-sensitive Site of Foot-and-Mouth Disease Virus1984 · 26 citations