Why the study?
Does major depression on intra-operative cerebral function monitoring correlate with postoperative neurological deficits and brain damage in patients undergoing cardiopulmonary bypass?
Does major depression on intra-operative cerebral function monitoring correlate with postoperative neurological deficits and brain damage in patients undergoing cardiopulmonary bypass?
Intra-operative cerebral function monitoring during cardiopulmonary bypass can identify patients at risk for ischemic brain damage and postoperative neurological deficits.
CFM depression ≥7 min was associated with deficits and infarction after bypass; leaves open whether monitoring improves outcomes.
Ischaemic lesions along cerebral arterial boundary zones were present in nine patients dying after cardiopulmonary by-pass. Their intra-operative cerebral function monitor recordings had shown at least 7 min major depression, its severity correlating with degrees of neurological deficit after operation and EEG abnormality and extent of infarction. In contrast eleven patients with normal or minimally abnormal cerebral function monitor recordings had macroscopically normal brains.
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Malone et al. (1981) studied this question.
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