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Provides standardized recommendations for the design, execution, and reporting of preclinical studies on thoracic aortopathy in mouse models to improve rigor and transparency.
There is a recent dramatic increase in research on thoracic aortic diseases that includes aneurysms, dissections, and rupture. Experimental studies predominantly use mice in which aortopathy is induced by chemical interventions, genetic manipulations, or both. Many parameters should be deliberated in experimental design in concert with multiple considerations when providing dimensional data and characterization of aortic tissues. The purpose of this review is to provide recommendations on guidance in (1) the selection of a mouse model and experimental conditions for the study, (2) parameters for standardizing detection and measurements of aortic diseases, (3) meaningful interpretation of characteristics of diseased aortic tissue, and (4) reporting standards that include rigor and transparency.
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Daugherty et al. (2025) conducted a review in Thoracic aortic diseases in preclinical models. This review provides recommendations for the design, execution, and reporting of studies on experimental thoracic aortopathy in preclinical mouse models to improve rigor and transparency.
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