Key result
Abdominal obesity measures are associated with increased proximal aortic intima-media thickness in adult African Americans, with waist circumference associated with thickness in all three segments.
Why the study?
Despite a high burden of overweight and cardiovascular disease among African Americans, limited data exist regarding the association between abdominal obesity and aortic wall thickness in this population.
Are abdominal obesity measures associated with increased aortic intima-media thickness in African Americans?
Cohort (n=1,572)
Are abdominal obesity measures associated with increased aortic intima-media thickness in African Americans?
Abdominal obesity measures, particularly waist circumference, are associated with increased aortic wall thickness in African Americans, highlighting a potential mechanism for increased cardiovascular risk.
Hypothesis-generating for abdominal obesity in aortic atherosclerosis among African Americans; prospective studies needed before clinical adoption.
OBJECTIVE: Abdominal obesity and wall thickness of the central arteries have been associated with higher risk of cardiovascular disease. Despite the higher burden of overweight and cardiovascular disease among African Americans, limited data are available on the association of abdominal obesity with aortic wall thickness in African Americans. We assessed the cross-sectional and the longitudinal associations of abdominal obesity with aortic intima-media thickness (aIMT) in a cohort of African Americans from the Jackson Heart Study. METHODS: Data on aIMT and repeated measures of waist circumference (WC) and waist to height ratio from 1,572 participants, as well as on abdominal subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and aIMT from 1,223 participants, were analyzed. aIMT was measured at proximal ascending aorta (PA-aIMT), proximal descending aorta (PD-aIMT), and distal aorta (bifurcation) using cardiac magnetic resonance. SAT and VAT were measured using computerized tomography. RESULTS: WC and WHtR were longitudinally associated with PA-aIMT and PD-aIMT; SAT and VAT were associated with PA-aIMT only. Only WC was associated with distal aIMT. CONCLUSIONS: Abdominal obesity measures are associated with increased proximal aIMT in adult African Americans. Only WC is associated with wall thickness in all three segments of the aorta.
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Mzayek et al. (2019) conducted a cohort in Abdominal obesity (n=1,572). Abdominal obesity (waist circumference, waist-to-height ratio, SAT, VAT) was evaluated on Aortic intima-media thickness (aIMT) at proximal ascending, proximal descending, and distal aorta. Abdominal obesity measures are associated with increased proximal aortic intima-media thickness in adult African Americans, with waist circumference associated with thickness in all three segments.
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