Key result
Volume overload significantly increased C-terminal ANP concentration, which was also significantly higher in cats with cardiomyopathy compared with normal cats.
Why the study?
Does plasma C-terminal ANP concentration correlate with left atrial pressure and indicate the presence of cardiomyopathy in cats?
Population
5 healthy adult cats, and 8 clinically healthy cats and 14 cats with cardiomyopathy. Total n=27.
Comparison
Volume overload with acetated Ringer's solution… vs Baseline and normal healthy cats.
Design
Preclinical
Follow-up
60 minutes (study 1)
Authors
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C-terminal ANP shows promise as feline cardiomyopathy biomarker; hypothesis-generating and requires prospective validation before clinical adoption.
Does plasma C-terminal ANP concentration correlate with left atrial pressure and indicate the presence of cardiomyopathy in cats?
Plasma C-terminal ANP concentration correlates with left atrial pressure and is elevated in cats with cardiomyopathy, suggesting its utility as a biomarker for feline heart disease.
Hori et al. (2008) studied Cardiomyopathy (n=27). Volume overload (Study 1) and Cardiomyopathy (Study 2) vs. Baseline (Study 1) and normal cats (Study 2) was evaluated on Plasma C-terminal ANP concentration. Volume overload significantly increased C-terminal ANP concentration, which was also significantly higher in cats with cardiomyopathy compared with normal cats.
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