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January 13, 2013Clinical Endocrinology

Central adrenal insufficiency in young adults with Prader‐Willi Syndrome

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To evaluate the prevalence and clinical predictors of central adrenal insufficiency in adults with Prader-Willi syndrome using the low-dose short synacthen test.
Assessed 53 adults with Prader-Willi syndrome (33 females) by measuring basal cortisol, ACTH, and 30-minute cortisol following 1 μg synacthen administration.
Defined intact adrenal function as a peak cortisol ≥500 nmol/l, retesting deficient individuals with high-dose or repeat low-dose synacthen tests.
Eight patients (15.1%) initially showed peak cortisol <500 nmol/l, presenting significantly lower mean basal cortisol (184.9 ± 32.0 nmol/l) than normal responders (364.1 ± 136.6 nmol/l; P < 0.001).
Upon retesting of 7 individuals, persistent central adrenal insufficiency was confirmed in 4 of 53 patients (7.5%), with female sex and baseline cortisol predicting peak response (adjusted R² = 0.505).

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Implication

Observational study reveals low prevalence of central adrenal insufficiency in adults with Prader-Willi syndrome, suggesting previous metyrapone-based rates were overestimated.

Cite This Study

Grugni et al. (2013) studied this question.

synapsesocial.com/papers/6a8afd4aa42d46e0ffcaa68e https://doi.org/10.1111/cen.12150

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Implication

Observational study reveals low prevalence of central adrenal insufficiency in adults with Prader-Willi syndrome, suggesting previous metyrapone-based rates were overestimated.

Central adrenal insufficiency in young adults with Prader‐Willi Syndrome

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Discussion

Implication

Cite This Study

Central adrenal insufficiency in young adults with Prader‐Willi Syndrome

Key Points

Discussion

Implication

Cite This Study

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