Why the study?
Does the calmodulin antagonist W7 improve intracellular calcium dynamics and LV function in a mouse model of myocardial stunning?
Does the calmodulin antagonist W7 improve intracellular calcium dynamics and LV function in a mouse model of myocardial stunning?
Inhibition of calmodulin-regulated mechanisms with W7 attenuates calcium overload and improves functional recovery in a mouse model of myocardial stunning.
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Preclinical only; leaves open whether calmodulin inhibition improves human myocardial stunning outcomes.
Hampton et al. (1998) studied this question.
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