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August 29, 1991New England Journal of Medicine

Abnormal Intracellular Modulation of Calcium as a Major Cause of Cardiac Contractile Dysfunction

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Implication

Abnormal calcium handling underlies contractile dysfunction; leaves open targeted therapies for clinical translation.

Key Points

Key points are not available for this paper at this time.

Cite This Study

A 1991 study studied this question.

synapsesocial.com/papers/6a7cd050069ec856dbbb529bhttps://doi.org/10.1056/nejm199108293250906

Topics

Heart failureHFrEF treatment
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regulation of Cardiac L-Type Calcium Current by Phosphorylation and G Proteins1990 · 361 citations
  2. 2Inotropic and calcium kinetic effects of calcium channel agonist and antagonist in isolated cardiac myocytes from cardiomyopathic hamsters.1990 · 46 citations
  3. 3Effect of ischemia on calcium-dependent fluorescence transients in rabbit hearts containing indo 1. Correlation with monophasic action potentials and contraction.1988 · 270 citations
  4. 4Skinned fibers of human atrium and ventricle: myosin isoenzymes and contractility.1988 · 77 citations
  5. 5Additive effects of dobutamine and amrinone on myocardial contractility and ventricular performance in patients with severe heart failure.1986 · 172 citations