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October 1, 1983AJP Heart and Circulatory Physiology

Control of cardiac contractility at the cellular level

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Population

Intact cardiac tissue, isolated cardiac sarcolemmal vesicles, isolated sarcoplasmic reticulum vesicles…

Design

Review

Authors

RCReg ChapmanUniversity of Otago

Discussion

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Implication

Species differences caution against extrapolating amphibian Ca2+ data to mammals; leaves open optimal model selection for translational contractility research.

Structured PICO

P
Population
Intact cardiac tissue, isolated cardiac sarcolemmal vesicles, isolated sarcoplasmic reticulum (SR) vesicles, isolated mitochondria, and cardiac contractile proteins (mammalian and amphibian heart models)
O
Outcome
Mechanisms of cardiac contractility and relaxation (Ca2+ cycling)

This review highlights the species-specific differences in cellular calcium handling and its role in cardiac contractility, emphasizing the primary role of the sarcoplasmic reticulum in mammalian hearts.

Cite This Study

Reg Chapman (1983) studied this question.

synapsesocial.com/papers/6a70d895a528af2d65c3c66dhttps://doi.org/10.1152/ajpheart.1983.245.4.h535
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ionic Basis of Myocardial Contractility1977 · 38 citations
  2. 2Integrative Analysis of Calcium Cycling in Cardiac Muscle2000 · 296 citations
  3. 3Ca regulation in cardiac muscle1991 · 47 citations
  4. 4Na‐Ca Exchange and Ca Fluxes during Contraction and Relaxation in Mammalian Ventricular Muscle<sup>a</sup>1996 · 121 citations
  5. 5Integrated Ca<sup>2+</sup> Management in Cardiac Myocytes2004 · 59 citations