April 1, 1996Annals of the New York Academy of Sciences
Na‐Ca Exchange and Ca Fluxes during Contraction and Relaxation in Mammalian Ventricular Musclea
Key result
In mammalian ventricular myocytes, the SR Ca-ATPase and Na-Ca exchange are the primary mechanisms for Ca removal, with the SR Ca-ATPase accounting for ~92% in rats and ~70% in other species.
Population
Mammalian ventricular myocytes (rat, rabbit, ferret, cat, and guinea pig)
Design
Preclinical
Authors
Discussion
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Implication
Urges caution extrapolating rodent SR Ca-ATPase dominance to humans; leaves open validation in human ventricular myocytes.
Structured PICO
P
Population
Mammalian ventricular myocytes (rat, rabbit, ferret, cat, and guinea pig)
E
Exposure
Evaluation of cellular Ca transport systems (SR Ca-ATPase, sarcolemmal Na-Ca exchange, sarcolemmal Ca-ATPase, and mitochondrial Ca uniporter)
O
Outcome
Relative roles of Ca transport systems in removing Ca from the myoplasm during the cardiac contraction-relaxation cyclesurrogate
The relative contribution of cellular calcium transport systems to myocardial relaxation varies significantly across mammalian species, with the SR Ca-ATPase being dominant in rats and Na-Ca exchange playing a larger role in other species.
Cite This Study
Bers et al. (1996) studied Normal cardiac contraction-relaxation cycle. In mammalian ventricular myocytes, the SR Ca-ATPase and Na-Ca exchange are the primary mechanisms for Ca removal, with the SR Ca-ATPase accounting for ~92% in rats and ~70% in other species.