May 1, 2004Annals of the New York Academy of Sciences
Integrated Ca2+ Management in Cardiac Myocytes
Key result
Calcium regulation within the cardiac myocyte is critical to normal heart function, and disruption of these processes can cause widely varied pathological effects, including arrhythmias and heart failure.
Population
Cardiac myocytes
Design
Review
Authors
Discussion
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Implication
Supports calcium handling as therapeutic target in arrhythmias and HF; leaves open optimal strategies pending prospective trials.
Structured PICO
P
Population
Cardiac myocytes
This review highlights the critical role of integrated calcium management in cardiac myocyte excitation-contraction coupling and its implications for arrhythmias and heart failure.
Cite This Study
Shannon et al. (2004) conducted a review in Heart failure and arrhythmias. Calcium regulation within the cardiac myocyte is critical to normal heart function, and disruption of these processes can cause widely varied pathological effects, including arrhythmias and heart failure.