Population
Recombinant rabbit cardiac and skeletal muscle Ca2+ release channels expressed in HEK-293 cells
Design
Preclinical
Authors
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RyR2 modulator insensitivity versus RyR1 may limit isoform extrapolation; leaves open targeted cardiac therapies pending further validation.
A novel [3H]ryanodine binding assay successfully characterized recombinant cardiac and skeletal muscle ryanodine receptors, revealing distinct sensitivities to physiological modulators.
Du et al. (1998) studied this question.
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