Key result
Concurrent CEA and CABG carries ~6% operative mortality, with aortic calcification strongly predicting death.
Cohort (n=311)
No
Concurrent carotid endarterectomy and CABG achieves acceptable perioperative morbidity and mortality with high 10-year freedom from neurological and coronary events, though proximal aortic atherosclerosis and systemic vasculopathy strongly predict adverse early and late outcomes.
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Concurrent CEA+CABG may be considered in select patients without aortic calcification; leaves open need for RCTs to guide timing versus staged approaches.
AIMS: To assess risk factors for early and late outcome after concurrent carotid endarterectomy (CEA) and coronary artery bypass grafting (CABG). METHODS AND RESULTS: Records of all 311 consecutive patients having concurrent CEA and CABG from 1989 to 2002 were reviewed, and follow-up obtained (100% complete). In the group (mean age 67 years; 74% males), 62% had triple-vessel disease, 57% unstable angina, 31% left main coronary stenosis, 19% congestive heart failure, and 35% either a history of vascular procedures or existing vasculopathies. Preoperative assessment revealed transient ischaemic attack in 16%, stroke in 7%, and bilateral carotid disease in 20%. There were 7% emergent and 19% urgent operations, and ascending aorta was described as atheromatous or calcified in 21%. Hospital death occurred in 19 patients, myocardial infarction in seven, and permanent stroke in 12. Significant multivariable predictors of hospital death were aortic calcifications, coexisting vasculopathy, and emergent procedure. Significant predictors of postoperative stroke were calcified or dilated aorta, and of prolonged hospital stay were advanced age, unstable angina, and coexisting vascular disease. For hospital survivors, 10-year actuarial late event-free rates were: death, 50%; myocardial infarction, 84%; stroke, 93%; percutaneous angioplasty, 95%; redo CABG, 98%; and all morbidity and mortality, 48%. Significant multivariable predictors of late deaths were coexisting vasculopathy, age, renal insufficiency, previous cardiac surgery, tobacco abuse, calcified or atheromatous aorta, and duration of intensive care unit stay. CONCLUSION: Concurrent CEA and CABG can be performed with acceptable operative mortality and morbidity, and good long-term freedom from coronary and neurologic events. Atheromatous aortic disease is a harbinger of poor operative and long-term outcome.
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Kolh et al. (2005) conducted a cohort in Concomitant severe carotid artery stenosis and coronary artery disease undergoing concurrent CEA and CABG (n=311). Concurrent carotid endarterectomy (CEA) and coronary artery bypass grafting (CABG) was evaluated on Operative (hospital) mortality. Concurrent CEA and CABG resulted in 6% hospital mortality, 4% permanent stroke, and 50% 10-year actuarial survival among hospital survivors, with aortic calcification strongly predicting operative death (OR 6.3).
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