Key result
Based on a comprehensive review of available data, clozapine and quetiapine appear to be the only true atypical antipsychotics when defined by freedom from extrapyramidal symptoms.
Design
Review
Authors
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Supports EPS-based reclassification of atypicals; hypothesis-generating and should not yet change prescribing.
This review suggests that among available atypical antipsychotics, only clozapine and quetiapine truly meet the classical definition of atypicality by avoiding extrapyramidal symptoms across their dosage ranges.
Andrew Farah (2005) conducted a review in Schizophrenia and bipolar disorder. Atypical antipsychotics vs. Conventional antipsychotics was evaluated. Based on a comprehensive review of available data, clozapine and quetiapine appear to be the only true atypical antipsychotics when defined by freedom from extrapyramidal symptoms.
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