Key result
In Japanese men with the Mt5178A genotype, daily alcohol consumption was associated with a significantly lower risk of mildly decreased eGFR compared to non-drinkers (OR 0.092).
Why the study?
Does habitual alcohol consumption combined with Mt5178 C/A polymorphism affect the risk of mildly decreased eGFR in male Japanese health check-up examinees?
Cross-Sectional (n=394)
No
Does habitual alcohol consumption combined with Mt5178 C/A polymorphism affect the risk of mildly decreased eGFR in male Japanese health check-up examinees?
Odds Ratio: 0.092 (95% CI 0.012–0.727)
p-value: p=0.024
Habitual alcohol consumption is associated with a reduced risk of mildly decreased eGFR in Japanese men with the Mt5178A genotype, but not in those with the Mt5178C genotype.
Does not support genotype-guided alcohol advice; hypothesis-generating for Mt5178A-specific renal associations in observational data.
BACKGROUND: Prevention of chronic kidney disease (CKD) is a major public health issue. Although several studies have been performed on the association between alcohol consumption and CKD or renal function, it remains controversial. Numerous genetic polymorphisms have been reported to be associated with CKD and kidney function. Mitochondrial DNA cytosine/adenine (Mt5178 C/A) polymorphism is associated with longevity in Japanese. This polymorphism modifies the effects of alcohol consumption on blood pressure, risk of hypertension, serum triglyceride levels, risk of hyper-LDL cholesterolemia and serum uric acid levels. The objective of this study was to investigate whether Mt5178 C/A polymorphism modifies the effects of alcohol consumption on renal function in male Japanese health check-up examinees. METHODS: A total of 394 male subjects aged 29-76 years were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the combined effects of Mt5178 C/A polymorphism and habitual drinking on the risk of mildly decreased estimated glomerular filtration rate (eGFR) (<90 ml/min/1.73 m(2)) was conducted. RESULTS: For Mt5178A genotypic men, habitual drinking may increase eGFR (P for trend = 0.003) or reduce the risk of mildly decreased eGFR (P for trend = 0.003). Daily drinkers had a significantly higher eGFR than non-drinkers (P = 0.005). The crude odds ratio for decreased eGFR was significantly lower in daily drinkers than in non-drinkers (odds ratio = 0.092, 95% confidence interval: 0.012-0.727, P = 0.024). On the other hand, for Mt5178C genotypic men, habitual drinking does not appear to affect eGFR. CONCLUSION: The present results suggest a joint effect of Mt5178 C/A polymorphism and alcohol consumption on eGFR and the risk of mildly decreased eGFR in male Japanese subjects.
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Kokaze et al. (2013) conducted a cross-sectional in Mildly decreased estimated glomerular filtration rate (eGFR) (n=394). Daily alcohol consumption (in Mt5178A genotype) vs. Non-drinkers was evaluated on Mildly decreased eGFR (<90 ml/min/1.73 m2) (OR 0.092, 95% CI 0.012-0.727, p=0.024). In Japanese men with the Mt5178A genotype, daily alcohol consumption was associated with a significantly lower risk of mildly decreased eGFR compared to non-drinkers (OR 0.092).
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