June 7, 1994Proceedings of the National Academy of SciencesOpen Access

Membrane repolarization stops caffeine-induced Ca2+ release in skeletal muscle cells.

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Population

rat skeletal myoballs

Design

Preclinical

Authors

NSNoriko SudaKeio University RPReinhold PennerUniversity of Hawaiʻi at Mānoa

Discussion

Member takes

Implication

Demonstrates repolarization-induced Ca2+ release shutdown in animals; extends bidirectional voltage control of SR channels but leaves open human translation.

Structured PICO

Population

rat skeletal myoballs

Intervention

Membrane repolarization after 10 mM caffeine-induced Ca2+ release

Outcome

Ca2+ release channel activity

Provides compelling evidence for a bidirectional voltage control (depolarization and repolarization) of the Ca2+-release channel in the sarcoplasmic reticulum.

Cite This Study

Suda et al. (1994) studied this question.

synapsesocial.com/papers/6a8b0626e76aab33123376a2 https://doi.org/10.1073/pnas.91.12.5725

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Implication

Demonstrates repolarization-induced Ca2+ release shutdown in animals; extends bidirectional voltage control of SR channels but leaves open human translation.

Membrane repolarization stops caffeine-induced Ca2+ release in skeletal muscle cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Membrane repolarization stops caffeine-induced Ca2+ release in skeletal muscle cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider