Key result
Surgical removal of pheochromocytoma significantly decreased serum C-reactive protein levels by 50% (from 0.49 to 0.23 mg/l, p<0.05) despite a significant increase in body weight.
Why the study?
Does surgical removal of pheochromocytoma reduce subclinical inflammation and alter adipose tissue endocrine function in patients with newly diagnosed pheochromocytoma?
Observational (n=18)
No
Does surgical removal of pheochromocytoma reduce subclinical inflammation and alter adipose tissue endocrine function in patients with newly diagnosed pheochromocytoma?
Absolute Event Rate: 0.235% vs 0.492%
p-value: p=<0.05
Surgical removal of pheochromocytoma significantly reduces subclinical inflammation and improves metabolic parameters despite weight gain, without altering circulating adipokines.
Supports reduced subclinical inflammation after pheochromocytoma resection despite weight gain; leaves open effects on adipokines and long-term outcomes.
The aim of our study was to evaluate the influence of surgical removal of pheochromocytoma on the endocrine function of adipose tissue and subclinical inflammation as measured by circulating C-reactive protein (CRP) levels. Eighteen patients with newly diagnosed pheochromocytoma were included into study. Anthropometric measures, biochemical parameters, serum CRP, leptin, adiponectin and resistin levels were measured at the time of diagnosis and six months after surgical removal of pheochromocytoma. Surgical removal of pheochromocytoma significantly increased body weight, decreased both systolic and diastolic blood pressure, fasting blood glucose and glycated hemoglobin levels. Serum CRP levels were decreased by 50 % six months after surgical removal of pheochromocytoma (0.49+/-0.12 vs. 0.23+/-0.05 mg/l, p<0.05) despite a significant increase in body weight. Serum leptin, adiponectin and resistin levels were not affected by the surgery. We conclude that increased body weight in patients after surgical removal of pheochromocytoma is accompanied by an attenuation of subclinical inflammation probably due to catecholamine normalization. We failed to demonstrate an involvement of the changes in circulating leptin, adiponectin or resistin levels in this process.
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Bošanská et al. (2009) conducted an observational in Pheochromocytoma (n=18). Surgical removal of pheochromocytoma vs. Baseline (pre-surgery) was evaluated on Serum C-reactive protein (CRP) levels (mg/l) (p=<0.05). Surgical removal of pheochromocytoma significantly decreased serum C-reactive protein levels by 50% (from 0.49 to 0.23 mg/l, p<0.05) despite a significant increase in body weight.
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