Why the study?
Does adriamycin induce remission in patients with advanced metastatic insulinoma refractory to conventional chemotherapy?
Does adriamycin induce remission in patients with advanced metastatic insulinoma refractory to conventional chemotherapy?
Adriamycin may be an effective treatment option for patients with advanced insulinoma who are unresponsive to conventional chemotherapy.
May support adriamycin consideration in refractory insulinoma; hypothesis-generating case report requiring prospective validation.
Two patients with advanced metastatic insulinoma are presented. Both failed to respond to streptozotocin and were refractory to other forms of chemotherapy. Therapy with adriamycin (Patient No. 1) and adriamycin plus 5-fluorouracil (Patient No. 2) led to significant decreases in insulin levels or measurable disease and both patients had clinical remissions lasting 5 to 7 months. Adriamycin may be effective in patients with advanced insulinoma unresponsive to conventional chemotherapy.
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Eastman et al. (1977) studied this question.
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