Key result
Asymptomatic or minimally symptomatic patients with newly diagnosed non-valvular atrial fibrillation had a higher rate of previous stroke compared to symptomatic patients (14.7% vs 6.0%, p<0.0001).
Why the study?
Do asymptomatic or minimally symptomatic patients with newly diagnosed NVAF have a higher rate of previous stroke compared to symptomatic patients?
Observational (n=6,011)
Yes
Do asymptomatic or minimally symptomatic patients with newly diagnosed NVAF have a higher rate of previous stroke compared to symptomatic patients?
Asymptomatic or minimally symptomatic patients with newly diagnosed atrial fibrillation have a significantly higher rate of previous stroke compared to symptomatic patients, highlighting the need for AF screening programs.
Answers are grounded in this paper and cite their sources.
Supports opportunistic AF screening to prevent silent strokes; leaves open whether systematic screening programs improve long-.
On behalf of: GLORIA-AF investigators Background: GLORIA-AF is a global, observational, registry program involving up to 56,000 patients (pts) with newly diagnosed, non-valvular atrial fibrillation (NVAF) at risk for stroke in 44 countries worldwide. Purpose: The aim of this sub-analysis was to compare patient characteristics between symptomatic (symp) and a-/minimally symptomatic (asymp) NVAF pts in Western Europe (WE). Methods: Eligibility requirements included NVAF in consecutive pts at risk for stroke (CHA2DS2-VASc score ≥1). Results: Characteristics of 6,011 enrolled pts are presented (table). The CHA2DS2-VASc scores did not differ in symp and asymp pts. However, 14.7% of asymp pts had a history of stroke prior to enrollment compared with 6.0% of symp pts (p< 0.0001). Conclusion: In WE two thirds of pts with NVAF are asymp. The high rate of previous stroke history in these pts despite no differences in CHA2DS2-VASc score may be explained by a longer, but occult AF history. These results underline demands for public programs to detect NVAF in the general population. Patient Characteristics Countries included in Westen Europe are Austria, Denmark, France, Germany, Greece, Ireland (Republic), Italy, The Netherlands, Norway, Portugal, Spain, Switzerland, United Kingdom and Belgium; Univariate logistic regressions were used
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Christow et al. (2017) conducted an observational in newly diagnosed, non-valvular atrial fibrillation (NVAF) at risk for stroke (n=6,011). Asymptomatic or minimally symptomatic NVAF vs. Symptomatic NVAF was evaluated on history of stroke prior to enrollment (p=< 0.0001). Asymptomatic or minimally symptomatic patients with newly diagnosed non-valvular atrial fibrillation had a higher rate of previous stroke compared to symptomatic patients (14.7% vs 6.0%, p<0.0001).
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