Key result
Rhinovirus infection in hospitalized children was associated with a 1.92 times lower probability of receiving an antibiotic prescription compared to negative RT-PCR results (p=0.011).
Why the study?
Acute viral respiratory tract infections present a significant challenge in pediatric healthcare globally, with rhinovirus being a primary etiological agent whose clinical characteristics and outcomes compared with other respiratory viruses needed evaluation.
What are the clinical characteristics and outcomes of rhinovirus infection compared with other respiratory viruses in hospitalized children?
Population
496 children hospitalized for influenza-like illness symptoms in Romania
Comparison
Rhinovirus infection vs other respiratory viruses or negative RT-PCR
Design
Retrospective study
Authors
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Describes rhinovirus features in hospitalized children; leaves open need for prospective validation of comparative outcomes.
Observational (n=496)
No
What are the clinical characteristics and outcomes of rhinovirus infection compared with other respiratory viruses in hospitalized children?
Effect estimate: 1.92 times lower probability
p-value: p=0.011
Rhinovirus is a highly prevalent cause of influenza-like illness in hospitalized children, and its identification via multiplex RT-PCR is associated with a significantly lower probability of antibiotic prescription compared to negative RT-PCR results.
Covaci et al. (2024) conducted an observational in Influenza-like illness (n=496). Rhinovirus infection vs. Negative RT-PCR results or other respiratory viruses was evaluated on Receiving an antibiotic prescription (1.92 times lower probability, p=0.011). Rhinovirus infection in hospitalized children was associated with a 1.92 times lower probability of receiving an antibiotic prescription compared to negative RT-PCR results (p=0.011).
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