The management of jaundice in patients with primary sclerosing cholangitis (PSC) is clinically challenging. In patients in whom the recognized precipitants for jaundice have been excluded, the outlook is uncertain at best. Some improve spontaneously, but the only treatment demonstrated to be effective is liver transplantation--which may not always be appropriate. We report three cases of jaundice in patients with PSC in whom corticosteroid therapy appeared to be beneficial.
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Parkes et al. (2001) studied this question.
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