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Reveals novel binding interactions between human alpha-thrombin and peptide boronic acids lacking a positive charge at P1, suggesting new structural strategies for protease inhibition.
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTCrystallographic Structures of Human α-Thrombin Complexed to Peptide Boronic Acids Lacking a Positive Charge at P1. Evidence of Novel InteractionsEmmanuel Skordalakes, Richard Tyrell, Said Elgendy, Christopher A. Goodwin, Donovan Green, Guy Dodson, Michael F. Scully, Jean-Marie H. Freyssinet, Vijay V. Kakkar, and John J. DeadmanView Author Information Thrombosis Research Institute Emmanuel Kaye Building, London SW3 6LR, U.K. Protein Structure Laboratory National Institute of Medical Research the Ridgeway, Mill Hill, London NW7 1AA, U.K. Faculté de Médecine Institut d'Hématologie et d'Immunologie 4 rue Kirschleger, F-67085 Strasbourg, France Cite this: J. Am. Chem. Soc. 1997, 119, 41, 9935–9936Publication Date (Web):October 15, 1997Publication History Received28 April 1997Published online15 October 1997Published inissue 1 October 1997https://pubs.acs.org/doi/10.1021/ja9713338https://doi.org/10.1021/ja9713338rapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views132Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstract
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Skordalakes et al. (1997) studied this question.
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