Population
Monolayer of cultured bovine aortic endothelium
Comparison
Various ACE inhibitors vs Comparison among ACE inhibitors with different…
Design
Preclinical
Authors
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Challenges assumption that lipophilicity governs ACE inhibitor endothelial access; leaves open relevance to human vascular effects.
The lipophilicity of ACE inhibitors does not influence their diffusion rate through cultured endothelium, suggesting the endothelium is not a specific barrier for their passage into the vessel wall.
Raasch et al. (1999) studied this question.
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