Population
Aortic rings
Comparison
Removal of endothelium by chemical or mechanical… vs Intact aortic rings (endothelium intact)
Design
Preclinical
Authors
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Suggests broader vascular ACE distribution in animals; leaves open relevance to human angiotensin metabolism or therapy.
Angiotensin converting enzyme activity is present in vascular cells other than the endothelium, suggesting local metabolism of angiotensin I within the vessel wall.
Pipili et al. (1989) studied this question.
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