Population
Rats (mesenteric artery tissue and plasma)
Comparison
Bilateral nephrectomy or adrenalectomy vs Sham-operated controls
Design
Preclinical
Follow-up
1 to 3 days
Authors
Loading...
Does not guide therapy; leaves open whether local vascular renin substrate contributes to human angiotensin II generation.
The study demonstrates the presence of renin substrate in rat mesenteric artery tissue, suggesting that all necessary components for local generation of angiotensin II are present within the wall of resistance vessels.
Desjardins-Giasson et al. (1981) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: