Why the study?
Does the use of homologous (rat) renin generate more angiotensin I compared to heterologous (rabbit) renin in rat plasma?
Population
Plasma from normal and bilaterally nephrectomized rats
Comparison
Incubation with an excess of rat renin vs Incubation with an excess of rabbit renin
Design
Preclinical
Authors
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No advantage of homologous renin in rat plasma assays; leaves open species specificity in other models or humans.
Does the use of homologous (rat) renin generate more angiotensin I compared to heterologous (rabbit) renin in rat plasma?
The study demonstrates that there is no species-specific renin substrate for homologous renin in normal or bilaterally nephrectomized rats.
Hiwada et al. (1979) studied this question.
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