January 1, 1971Scandinavian Journal of Clinical and Laboratory Investigation

No Evidence of Active Renin-Inhibitors in Plasma. The Kinetics of the Reaction between Renin and Substrate in Non-pre-treated Plasma

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Population

Plasma and serum from normal, salt-depleted, 24-hour and 48-hour nephrectomized, and experimentally…

Design

Preclinical

Authors

KPKnud PoulsenSdPhotonics (United States)

Discussion

Member takes

Implication

Supports standard kinetic models for renin activity; leaves open human applicability and inhibitor roles in disease.

Structured PICO

Population

Plasma and serum from normal, salt-depleted, 24-hour and 48-hour nephrectomized, and experimentally hypertensive rats

Intervention

Addition of small physiological amounts of purified renal rat renin

Outcome

Rate of reaction between renin and its substrate (endogenous substrate consumption with time)surrogate

This preclinical study found no evidence of active renin-inhibitors in rat plasma, showing that the renin-substrate reaction follows Michaelian kinetics.

Cite This Study

Knud Poulsen (1971) studied this question.

synapsesocial.com/papers/6a7cd87ce9867978b6a1e272 https://doi.org/10.3109/00365517109080187

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No Evidence of Active Renin-Inhibitors in Plasma. The Kinetics of the Reaction between Renin and Substrate in Non-pre-treated Plasma

Discussion

Member takes

Implication

Structured PICO

Cite This Study

No Evidence of Active Renin-Inhibitors in Plasma. The Kinetics of the Reaction between Renin and Substrate in Non-pre-treated Plasma

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider