July 1, 1968Biochemical JournalOpen Access

Properties of renin substrate in rabbit plasma with a note on its assay

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Population

Rabbit plasma

Design

Preclinical

Authors

Discussion

Enables renin substrate assay in rabbit plasma; leaves open translation to human clinical samples.

Population

Rabbit plasma

Intervention

Combination of 2,3-dimercaptopropan-1-ol (10mm), EDTA (10mm) and chlorhexidine gluconate (0.005%, w/v) as selective inhibitors

Outcome

Measurement of renin substrate concentration as angiotensin I contentsurrogate

Presents a method for assaying renin substrate in rabbit plasma using selective inhibitors that prevent angiotensin I degradation.

Ryan et al. (1968) studied this question.

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