Why the study?
Does temocapril effectively block angiotensin II generation and reduce pressor responses to angiotensin I in normal volunteers?
Population
10 normal volunteers
Comparison
Temocapril (different doses) vs Placebo
Design
Other, double-blind
Authors
Loading...
Ang II/Ang I ratio tracks ACE inhibitor efficacy on BP; confirms PK-PD linkage for temocapril in volunteers.
Does temocapril effectively block angiotensin II generation and reduce pressor responses to angiotensin I in normal volunteers?
In vivo ACE activity, estimated by the plasma Ang II/Ang I ratio, reliably predicts the decrease in angiotensin-dependent blood pressure achieved by ACE inhibitors.
Delacrétaz et al. (1994) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: