Cobalamin and the Nervous System

To the stalwart little band of investigators of vitamin B12 — now more rationally termed cobalamin — there is comfort in knowing that the stream of important scientific problems will never end. If the past is any guide to the future, they will be difficult problems inciting tumult and controversy, and in the end they will yield broad biologic insights and many surprises.Certainly these have been the hallmarks of the rich history of cobalamin research to date.1 It began with the Nobel prize–winning observation of Minot and Murphy that feeding the patient liver reverses the disastrous course of . . .