Population
Simulated data and literature data for single ion channel behaviour
Comparison
Likelihood-based estimation procedures for… vs Moment methods based on single exponential…
Design
Other
Authors
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Higher-order approximations enable unique ion channel model parameters; leaves open experimental validation in cardiovascular electrophysiology.
The study demonstrates that higher-order approximations in two-state Markov models for single ion channels yield theoretically identifiable models, overcoming the non-uniqueness of single exponential approximations.
Milne et al. (1988) studied this question.
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