Radiotherapy in acromegaly: the argument against

External pituitary irradiation (XRT) has been used as a thera-peutic modality in patients with acromegaly for the past 100 years. Multiple studies have demonstrated the slow but inexorable decline of plasma GH for as long as 20–25 years after the procedure, with some 70–90 % of patients ultimately achieving plasma GH levels below 5 m