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Effect of TRH administration on serum TSH and GH was studied in 9 normal subjects and 11 patients with acromegaly or gigantism. TRH provoked a prompt increase of serum TSH in normal subjects, whereas no appreciable change of serum GH was observed. Serum TSH responses to TRH were lower in most of the patients, but 8 out of the patients showed a remarkable increase of serum GH within 30 min after TRH injection. These results appear to indicate that specificity of TRH is not absolute in the functioning pituitary tumor secreting GH.
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Irie et al. (1972) studied this question.
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