Key result
A mathematical model of the rat early distal convoluted tubule suggests that most peritubular Cl(-) reabsorption proceeds via a KCl cotransporter and early DCT HCO(3)(-) reabsorption is mediated by a luminal Na(+)/H(+) exchanger.
Population
Mathematical model of rat early distal convoluted tubule (DCT)
Design
Preclinical
Authors
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Model predictions on DCT transport are hypothesis-generating; experimental validation required before clinical relevance in volume or K+ homeostasis.
A mathematical model of the rat early distal convoluted tubule suggests that volume-dependent inhibition of the thiazide-sensitive NaCl cotransporter may contribute to volume homeostasis and renal K+ excretion.
Alan M. Weinstein (2005) studied this question. Mathematical model of rat early distal convoluted tubule was evaluated. A mathematical model of the rat early distal convoluted tubule suggests that most peritubular Cl(-) reabsorption proceeds via a KCl cotransporter and early DCT HCO(3)(-) reabsorption is mediated by a luminal Na(+)/H(+) exchanger.
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