This review highlights the importance of both macrovascular and microvascular complications in diabetes mellitus, including potential pathogenetic mechanisms.
Highlights ongoing relevance of microangiopathy in diabetes care; leaves open mechanistic insights for therapeutic development.
The vascular complications occurring in diabetes mellitus are reviewed. In addition to the long recognised involvement of large vessels by atheroma and Monckeberg's sclerosis, the more recently described microangiopathy affecting arterioles, venules and, in particular, capillaries is also described. The significance of this microangiopathy in the diabetic syndrome is outlined, and possible pathogenetic mechanisms involved in its development are discussed.
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R. N. M. MacSween (1971) studied this question.
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