What question did this study set out to answer?

To evaluate plasma aldosterone concentration across different functional severity classes in dogs with chronic heart failure and assess hormonal changes following vasodilator therapy.

November 1, 1983Journal of the American Veterinary Medical Association

Comparison of plasma aldosterone concentration among clinical status groups of dogs with chronic heart failure

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Why the study?

Does heart failure severity and treatment with captopril or hydralazine affect plasma aldosterone concentration in dogs with chronic heart failure?

Key Points

To evaluate plasma aldosterone concentration across different functional severity classes in dogs with chronic heart failure and assess hormonal changes following vasodilator therapy.
Measured plasma aldosterone concentration (PAC) in 23 dogs with chronic heart failure stratified by New York Heart Association (NYHA) classes III and IV compared to clinically normal controls.
Assessed circulating PAC changes following therapeutic administration of either captopril or hydralazine.
Dogs in NYHA class IV (P < 0.0001) and class III (P < 0.01) exhibited significantly elevated PAC compared to normal controls, with class IV PAC significantly exceeding class III levels (P < 0.01).
PAC levels did not differ markedly between dogs with severe, poor-prognosis NYHA class IV disease and those with recent-onset NYHA class IV disease.
Post-treatment PAC decreased significantly in dogs receiving captopril (P < 0.01), whereas dogs treated with hydralazine showed significant PAC increases (P < 0.05).

Structured PICO

Does heart failure severity and treatment with captopril or hydralazine affect plasma aldosterone concentration in dogs with chronic heart failure?

Population

23 dogs with chronic heart failure (18 admitted in NYHA class IV, 5 in NYHA class III)

Intervention

Captopril or hydralazine therapy

Comparator

Clinically normal dogs (for baseline comparison)

Outcome

Plasma aldosterone concentration (PAC)surrogate

Heart failure severity in dogs correlates with increased plasma aldosterone concentration, which is decreased by captopril and increased by hydralazine.

Discussion

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Implication

Severity-dependent PAC elevation in dogs is attenuated by captopril but increased by hydralazine; leaves open clinical translation and outcome impact.

Cite This Study

Knowlen et al. (1983) studied this question.

synapsesocial.com/papers/6a8b2a432ff0ab4f91e950c1 https://doi.org/10.2460/javma.1983.183.09.991

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Implication

Severity-dependent PAC elevation in dogs is attenuated by captopril but increased by hydralazine; leaves open clinical translation and outcome impact.

Comparison of plasma aldosterone concentration among clinical status groups of dogs with chronic heart failure

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Comparison of plasma aldosterone concentration among clinical status groups of dogs with chronic heart failure

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider