January 1, 1999Journal of Veterinary Medical ScienceOpen Access

Plasma Atrial and Brain Natriuretic Peptide Levels in Dogs with Congestive Heart Failure.

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Population

6 dogs with experimental mitral regurgitation, 19 canine patients with asymptomatic and symptomatic…

Design

Preclinical

Authors

KAKazushi AsanoNihon University KMKeiko MasudaRIKEN Center for Biosystems Dynamics Research MOMasahiro OkumuraHokkaido University of Science

Discussion

Member takes

Implication

Supports ANP/BNP evaluation as canine HF biomarkers; hypothesis-generating and should not yet change practice.

Structured PICO

Population

6 dogs with experimental mitral regurgitation (MR), 19 canine patients with asymptomatic and symptomatic congestive heart failure (CHF) (median age 11 years, 14 males/5 females), and 19 healthy control dogs.

Intervention

Measurement of plasma atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) concentrations.

Outcome

Correlation of plasma ANP and BNP concentrations with pulmonary capillary wedge pressure (PCWP) and severity of heart failure (NYHA class).surrogate

Plasma ANP and BNP levels correlate with pulmonary capillary wedge pressure and heart failure severity in dogs, suggesting their utility as biomarkers in veterinary cardiology.

Limitations

Discrepancy between spontaneous and experimental MR
PCWP does not always reflect clinical signs of heart failure in dogs with chronic spontaneous MR
Limited clinical cases to determine effects of underlying cardiac disease, aging, breed, and treatment
Lower sensitivity of the assay for canine BNP

Cite This Study

Asano et al. (1999) studied this question.

synapsesocial.com/papers/6a93c0e7744b618ad237ee28 https://doi.org/10.1292/jvms.61.523

Topics

Heart failure HFrEF treatment Mitral valve intervention

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Plasma Atrial and Brain Natriuretic Peptide Levels in Dogs with Congestive Heart Failure.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Plasma Atrial and Brain Natriuretic Peptide Levels in Dogs with Congestive Heart Failure.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider