Key result
Higher plasma NT-proBNP concentrations were significantly correlated with mitral regurgitation severity and predicted MVD decompensation at 12 months in dogs with asymptomatic MVD (P<0.05).
Why the study?
Does NT-proBNP correlate with mitral regurgitation severity and predict disease progression in dogs with asymptomatic degenerative mitral valve disease?
Population
72 dogs with asymptomatic degenerative mitral valve disease, with or without heart enlargement, and a…
Comparison
Measurement of plasma N-terminal pro-B-type… vs Control group of 22 dogs, and comparison across…
Design
Cohort
Follow-up
12 months
Authors
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May support NT-proBNP monitoring in asymptomatic canine MVD; leaves open whether it guides therapy or improves outcomes.
Cohort (n=94)
Does NT-proBNP correlate with mitral regurgitation severity and predict disease progression in dogs with asymptomatic degenerative mitral valve disease?
p-value: p=< .05
Plasma NT-proBNP concentration correlates with echocardiographic indices of mitral regurgitation severity and predicts early decompensation in dogs with asymptomatic degenerative mitral valve disease.
Chetboul et al. (2009) conducted a cohort in Asymptomatic Degenerative Mitral Valve Disease (n=94). Plasma N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) concentration vs. Control group / lower NT-proBNP was evaluated on MVD decompensation at 12 months and correlation with MR severity (p=< .05). Higher plasma NT-proBNP concentrations were significantly correlated with mitral regurgitation severity and predicted MVD decompensation at 12 months in dogs with asymptomatic MVD (P<0.05).
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