Population
Mutant yeast actin (V266G/L267G, GG-actin) and WT-actin
Comparison
Polymerization conditions, temperature changes… vs WT-actin
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether unstable actin oligomers contribute to human cardiac cytoskeletal disorders.
The study demonstrates that a polymerization-defective yeast actin mutant exhibits continuous F-actin-like ATPase activity due to unstable oligomer formation, which can be stabilized by tropomyosin.
Yao et al. (2001) studied this question.
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