Comparison of clinical and biochemical parameters in the ovulatory and anovulatory phenotypes of polycystic ovary syndrome

Aims: We aimed to compare the clinical and the biochemical features of the ovulatory versus anovulatory phenotypes of polycystic ovary syndrome (PCOS). Methods: This is a retrospective controlled trial conducted among the women who applied to the İstanbul Liv Vadi Hospital between 2021 and 2023 August and diagnosed as PCOS. PCOS patients (n=290) were diagnosed according to the Rotterdam 2003consensus criteria. Women’s clinical and biochemical parameters such as age, height, weight, body mass index (BMI), waist, hip, waist/hip ratio (WHR), fasting blood sugar (FBS), insulin, homeostatic model-assessment-insulin resistance (HOMA-IR), antimullerian hormone (AMH), follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2) total cholesterol,triglyceride, dehydroepiandrosterone (DHEAS), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) of participants were compared between ovulatory and anovulatory phenotypes. Results: The findings of the study did not demonstrate a statistically significant correlation between ovulatory and anovulatory phenotypes in relation to various factors, including height, weight, BMI, waist circumference, hip circumference, WHR, insulin levels, HOMA-IR, AMH, FSH, E2, TSH, total cholesterol, testosterone, free testosterone, DHEAS, LDL and cholesterol (p-value>0.05). A statistically significant difference was observed between the groups in terms of age, FBS, BMI, LH, and HDL levels. Conclusion: In conclusion, there is no significant difference in PCOS’s ovulatory and anovulatory phenotypes in essential parameters such as insulin resistance and BMI.