Key result
Cardiac fluctuations significantly affect the resting state hemodynamic response height in the brainstem and surrounding cortical areas, though the point process HRF remains a robust marker of brain activity.
Observational (n=21)
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Cardiac fluctuations significantly affect the resting state point process hemodynamic response height in the brainstem and surrounding cortical areas, though test-retest reliability remains robust.
It has been shown that resting state brain dynamics can be characterized by looking at sparse blood-oxygen-level dependent (BOLD) events, which can be retrieved by point process analysis. Cardiac activity can also induce changes in the BOLD signal, thus affect both the number of these events and the mapping between neural events and BOLD signal, namely the hemodynamic response. To isolate neural activity and autonomic effects, we compare the resting state hemodynamic response retrieved by means of a point process analysis with and without deconvolving the cardiac fluctuations. Brainstem and the surrounding cortical area (such as precuneus, insula etc.) are found to be significantly affected by cardiac pulses. Methodological and physiological implications are then discussed.
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Wu et al. (2015) conducted an observational in Healthy (resting state) (n=21). Cardiac fluctuation correction models vs. Without cardiac fluctuation correction was evaluated on Hemodynamic response function (HRF) response height (p=<0.05). Cardiac fluctuations significantly affect the resting state hemodynamic response height in the brainstem and surrounding cortical areas, though the point process HRF remains a robust marker of brain activity.
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