Why the study?
Does the addition of torsemide to warfarin potentiate the anticoagulant effect of warfarin?
Does the addition of torsemide to warfarin potentiate the anticoagulant effect of warfarin?
Torsemide may potentiate the anticoagulant effect of warfarin, likely through CYP2C9 competition and protein-binding displacement, requiring close INR monitoring when co-administered.
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Torsemide may elevate INR on warfarin; this case report leaves open confirmation of a clinically relevant interaction.
Bird et al. (2008) studied this question.
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