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CADM1 and CADM2 trigger neuropathogenic measles virus-mediated membrane fusion by acting in cis.
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Measles virus (MeV), an enveloped RNA virus, is the causative agent of measles, which is still an important cause of childhood morbidity and mortality worldwide. Persistent MeV infection in the brain causes a fatal progressive neurological disorder, subacute sclerosing panencephalitis (SSPE), several years after acute infection.
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Shirogane et al. (2021) studied this question. CADM1 and CADM2 trigger neuropathogenic measles virus-mediated membrane fusion by acting in cis.
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