Key result
Carotid sinus nerve transection in male mice abolished the facilitation of breathing upon cessation of a hypercapnic gas challenge, demonstrating the essential role of carotid body chemoafferents.
Why the study?
Does carotid sinus nerve transection abolish the facilitation of breathing during and after a hypercapnic gas challenge in male mice?
Does carotid sinus nerve transection abolish the facilitation of breathing during and after a hypercapnic gas challenge in male mice?
This study provides the first evidence that carotid body chemoafferents are essential for initiating and maintaining ventilatory responses to hypercapnia in mice.
This study presents the first evidence that carotid body chemoafferents play a key role in initiating the ventilatory responses, such as increases in frequency of breathing, tidal volume, and minute ventilation that occur in response to a hypercapnic gas challenge in freely moving C57BL6 mice. Our study also demonstrates for the first time that these chemoafferents are essential for the expression of the ventilatory responses that occur upon return to room air in these mice.
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Getsy et al. (2021) studied this question. Carotid sinus nerve transection was evaluated on Ventilatory responses (frequency of breathing, tidal volume, and minute ventilation) to hypercapnic gas challenge and return to room air. Carotid sinus nerve transection in male mice abolished the facilitation of breathing upon cessation of a hypercapnic gas challenge, demonstrating the essential role of carotid body chemoafferents.
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